Publikationen
Khan, M., Clijsters, M., Choi, S., Backaert, W., Claerhout, M., Couvreur, F., Van Breda, L., Bourgeois, F., Speleman, K., Klein, S., Van Laethem, J., Verstappen, G., Dereli, A.S., Yoo, S.J., Zhou, H., Do, T.N.D., Jochmans, D., Laenen, L., Debaveye, Y., De Munter, P., Gunst, J., Jorissen, M., Lagrou, K., Meersseman, P., Neyts, J., Thal, D.R., Topsakal, V., Vandenbriele, C., Wauters, J., Mombaerts, P., and Van Gerven, L. (2022). Anatomical barriers against SARS-CoV-2 neuroinvasion at vulnerable interfaces visualized in deceased COVID-19 patients. Neuron 110, 3919-3935. https://doi.org/10.1016/j.neuron.2022.11.007
Khan, M., Yoo, S.J., Clijsters, M., Backaert, W., Vanstapel, A., Speleman, K., Lietaer, C., Choi, S., Hether, T.D., Marcelis, L., Nam, A., Pan, L., Reeves, J.W., Van Bulck, P., Zhou, H., Bourgeois, M., Debaveye, Y., De Munter, P., Gunst, J., Jorissen, M., Lagrou, L., Lorent, N., Neyrinck, A., Peetermans, M., Thal, D.R., Vandenbriele, C., Wauters, J., Mombaerts, P., and Van Gerven, L. (2021). Visualizing in deceased COVID-19 patients how SARS-CoV-2 attacks the respiratory and olfactory mucosae but spares the olfactory bulb. Cell 184, 5932-5949. https://doi.org/10.1016/j.cell.2021.10.027
Koike, K., Yoo, S.J., Bleymehl, K., Omura, M., Zapiec, B., Pyrski, M., Blum, T., Khan, M., Bai, Z., Leinders-Zufall, T., Mombaerts, P., and Zufall, F. (2021). Danger perception and stress response through an olfactory sensor for the bacterial metabolite hydrogen sulfide. Neuron 109, 2469-2484. https://doi.org/10.
Ceulemans, L.J., Khan, M., Yoo, S. J., Zapiec, B., Van Gerven, L., Van Slambrouck, J., Vanstapel, A., Van Raemdonck, D., Vos, R., Wauters, E., Wauters, J., Carmeliet, P., and Mombaerts, P. (2021). Persistence of SARS-CoV-2 RNA in lung tissue after mild COVID-19. Lancet Respir. Med. 9, e78-e79. https://doi.org/10.1016/S2213-
Zapiec, B., and Mombaerts, P. (2020). The zonal organization of odorant receptor gene choice in the main olfactory epithelium of the mouse. Cell Reports 30, 4220–4234. https://doi.org/10.1016/j.celrep.2020.02.110
Barnes, I.H.A., Ibarra-Soria, X., Fitzgerald, S., Gonzalez, J.M., Davidson, C., Hardy, P., Manthravadi, D., Van Gerven, L., Jorissen, M., Zeng, Z., Khan, M., Mombaerts, P., Harrow, J., Logan, D.W., and Frankish, A. (2020). Expert curation of the human and mouse olfactory receptor gene repertoires identifies conserved coding regions split across two exons. BMC Genomics 21, 196. https://doi.org/10.1186/s12864-020-6583-3
Bufe, B., Teuchert, Y., Schmid, A., Pyrski, M., Pérez-Gómez, A., Eisenbeis, J., Timm, T., Ishii, T., Lochnit, G., Bischoff, M., Mombaerts, P., Leinders-Zufall T., and Zufall, F. (2019). Bacterial MgrB peptide activates chemoreceptor Fpr3 in mouse accessory olfactory system and drives avoidance behaviour. Nat. Commun. 10, 4889. https://doi.org/10.1038/s41467-019-12842-x
Saraiva, L.R., Riveros-McKay, F., Mezzavilla, M., Abou-Moussa, E.H., Arayata, C.J., Makhlouf, M., Trimmer, C., Ibarra-Soria, X., Khan, M., Van Gerven, L., Jorissen, M., Gibbs, M., O’Flynn, C., McGrane, S., Mombaerts, P., Marioni, J.C., Mainland, J.D., and Logan D.W. (2019). A transcriptomic atlas of mammalian olfactory mucosae reveals an evolutionary influence on food odor detection in humans, Sci. Adv. 5. https://doi.org/10.1126/sciadv.aax0396
Zhou, H., Zeng, Z., Koentgen, F., Khan, M, and Mombaerts, P. (2019). The testicular soma of Tsc22d3 knockout mice supports spermatogenesis and germline transmission from spermatogonial stem cell lines upon transplantation. Genesis 5, e23295. https://doi.org/10.1002/dvg.23295
Torres-Torrelo, H., Ortega-Sáenz, P., Macías, D., Omura, M., Zhou, T., Matsunami, H., Johnson, R.S., Mombaerts, P., and López-Barneo, J. (2018). The role of Olfr78 in the breathing circuit of mice. Nature 561, E33-E40. DOI: https://doi.org/10.1038/s41586-018-0545-9
Akiyoshi, S., Ishii, T., Bai, Z., and Mombaerts, P. (2018). Subpopulations of vomeronasal sensory neurons with coordinated coexpression of type 2 vomeronasal receptor genes are differentially dependent on Vmn2r1. Eur. J. Neurosci. 47, 887-900. DOI: https://doi.org/10.1111/ejn.13875
Katidou, M., Grosmaitre, X., Lin, J., and Mombaerts, P. (2018). G-protein coupled receptors Mc4r and Drd1a can serve as surrogate odorant receptors in mouse olfactory sensory neurons. Mol. Cell Neurosci. 88, 138-147. DOI: https://doi.org/10.1016/j.mcn.2018.01.010.
Richter, K.N., Revelo, N.H., Seitz, K.J., Helm, M.S., Sarkar, D., Saleeb, R.S., D'Este, E., Eberle, J., Wagner, E., Vogl, C., Lazaro, D.F., Richter, F., Coy‐Vergara, J., Coceano, G., Boyden, E.S., Duncan, R.R., Hell, S.W., Lauterbach, M.A., Lehnart, S.E., Moser, T., Outeiro, T.F., Rehling, P., Schwappach, B., Testa, I., Zapiec, B., and Rizzoli, S.O. (2018). Glyoxal as an alternative fixative to formaldehyde in immunostaining and super‐resolution microscopy. EMBO J. 37, 139-159. DOI: https://doi.org/10.15252/embj.201695709
Zapiec, B., Dierks, B.V., Tan, S., Faull, R.L.M., Mombaerts, P., and Curtis, M.A. (2017). A ventral glomerular deficit in Parkinson’s disease revealed by whole olfactory bulb reconstruction. Brain 140, 2722-2736. DOI: https://doi.org/10.1093/brain/awx208
Lin, J., Khan, M., Zapiec, B., and Mombaerts, P. (2017). PDGFRA is not essential for the derivation and maintenance of mouse extraembryonic endoderm stem cell lines. Stem Cell Reports 9, 1062-1070. DOI: https://doi.org/10.1016/j.stemcr.2017.08.005
Low, V., and Mombaerts, P. (2017). Odorant receptor proteins in the mouse main olfactory epithelium and olfactory bulb. Neuroscience 344, 167-177. DOI: https://doi.org/10.1016/j.neuroscience.2016.12.044
Lin, J., Khan, M., Zapiec, B., and Mombaerts, P. (2016). Efficient derivation of extraembryonic endoderm stem cell lines from mouse postimplantation embryos. Sci. Rep. 6, 39457. DOI: https://doi.org/10.1038/srep39457
Bleymehl, K., Pérez-Gómez, A., Omura, M., Moreno-Pérez, A., Macias, D., Bai, Z., Johnson, R.S., Leinders-Zufall, T., Zufall, F., and Mombaerts, P. (2016), A sensor for low environmental oxygen in the mouse main olfactory epithelium. Neuron 92, 1196–1203; DOI: https://doi.org/10.1016/j.neuron.2016.11.001
Zapiec, B., Bressel, O.C., Khan, M., Walz, A., and Mombaerts, P. (2016). Neuropilin-1 and the positions of glomeruli in the mouse olfactory bulb. eneuro, ENEURO.0123-16.2016; DOI: https://doi.org/10.1523/ENEURO.0123-16.2016
Koentgen, F., Lin, J., Katidou, M., Chang, I., Khan, M., Watts, J. and Mombaerts, P. (2016). Exclusive transmission of the embryonic stem cell-derived genome through the mouse germline. genesis, 54: 326–333. DOI: https://doi.org/10.1002/dvg.22938
Bressel, O.C., Khan, M., and Mombaerts, P. (2016). Linear correlation between the number of olfactory sensory neurons expressing a given mouse odorant receptor gene and the total volume of the corresponding glomeruli in the olfactory bulb. J. Comp. Neurol. 524, 199-209. DOI: https://doi.org/10.1002/cne.23835
Tazir, B., Khan, M., Mombaerts, P., and Grosmaitre, X. (2016). The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256-17 includes TAAR ligands. Eur. J. Neurosci., DOI: https://doi.org/10.1111/ejn.13153.
Saraiva, L.R., Ibarra-Soria, X., Khan, M., Omura, M., Scialdone, A., Mombaerts, P., Marioni, J.C., and Logan, D.W. (2015). Hierarchical deconstruction of mouse olfactory sensory neurons: from whole mucosa to single-cell RNA-seq. Sci. Rep. 5, 18178. DOI: https://doi.org/10.1038/srep18178
Zapiec, B., and Mombaerts, P. (2015). Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography. Proc. Natl. Acad. Sci. USA 112, E5873-5882. DOI: https://doi.org/10.1073/pnas.1512135112
Omura, M., and Mombaerts, P. (2015). Trpc2-expressing sensory neurons in the mouse main olfactory epithelium of type B express the soluble guanylate cyclase Gucy1b2. Mol. Cell. Neurosci. 65, 114-124. DOI: https://doi.org/10.1016/j.mcn.2015.02.012
Omura, M., and Mombaerts, P. (2014). Trpc2-expressing sensory neurons in the main olfactory epithelium of the mouse. Cell Rep. 8, 583-595. DOI: https://doi.org/10.1016/j.celrep.2014.06.010
Leinders-Zufall, T., Ishii, T., Chamero, P., Hendrix, P., Oboti, L., Schmid, A., Kircher, S., Pyrski, M., Akiyoshi, S., Khan, M., Vaes, E., Zufall, F., and Mombaerts, P. (2014). A family of nonclassical class I MHC genes contributes to ultrasensitive chemodetection by mouse vomeronasal sensory neurons. J. Neurosci. 34, 5121-5133. DOI: https://doi.org/10.1523/JNEUROSCI.0186-14.2014
Omura, M., Grosmaitre, X., Ma, M., and Mombaerts, P. (2014). The beta2-adrenergic receptor as a surrogate odorant receptor in mouse olfactory sensory neurons. Mol. Cell. Neurosci. 58, 1-10. DOI: https://doi.org/10.1016/j.mcn.2013.10.010
Khan, M., Vaes, E., and Mombaerts, P. (2013). Temporal patterns of odorant receptor gene expression in adult and aged mice. Mol. Cell. Neurosci. 57, 120-129. DOI: https://doi.org/10.1016/j.mcn.2013.08.001
Lam, R.S., and Mombaerts, P. (2013). Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23. Eur. J. Neurosci. 38, 2210-2217. DOI: https://doi.org/10.1111/ejn.12240
Khan, M., Vaes, E., Mombaerts, P. (2011). Regulation of the probability of odorant receptor gene choice in mouse. Cell 147, 907-921. DOI: https://doi.org/10.1016/j.cell.2011.09.049
Leinders-Zufall, T., Ishii, T., Mombaerts, P., Zufall, F., and Boehm, T. (2009). Structural requirements for the activation of vomeronasal sensory neurons by MHC peptides. Nat. Neurosci. 12, 1551-1558. DOI: https://doi.org/10.1038/nn.2452
Grosmaitre, X., Fuss, S.H., Lee, A.C., Adipietro, K.A., Matsunami H., Mombaerts, P., and Ma, M. (2009). SR1, a mouse odorant receptor with an unusually broad response profile. J. Neurosci. 29, 14545-14552. DOI: https://doi.org/10.1523/JNEUROSCI.2752-09.2009
Bozza, T., Vassalli, A., Fuss, S., Zhang, J., Weiland, B., Pacifico, R., Feinstein, P., and Mombaerts, P. (2009). Mapping of class I and class II odorant receptors to glomerular domains by two distinct types of olfactory sensory neurons in the mouse. Neuron 61, 220-233. DOI: https://doi.org/10.1016/j.neuron.2008.11.010
Li, J., and Mombaerts, P. (2008). Nuclear transfer-mediated rescue of the nuclear genome of nonviable mouse cells frozen without cryoprotectant. Biol. Reprod. 79, 588-593. DOI: https://doi.org/10.1095/biolreprod.108.069583
Ishii, T., and Mombaerts, P. (2008). Expression of non-classical class I major histocompatibility genes defines a tripartite organization of the mouse vomeronasal system. J. Neurosci. 28, 2332-2341. DOI: https://doi.org/10.1523/JNEUROSCI.4807-07.2008
Fuss, S.H., Omura, M., and Mombaerts, P. (2007). Local and cis effects of the H element on expression of odorant receptor genes in mouse. Cell 130, 373-384. DOI: https://doi.org/10.1016/j.cell.2007.06.023
Li, J., Greco, V., Guasch, G., Fuchs, E., and Mombaerts, P. (2007). Mice cloned from skin cells. Proc. Natl. Acad. Sci. USA 104, 2738-2743. DOI: https://doi.org/10.1073/pnas.0611358104
Hirota, J., Omura, M., and Mombaerts, P. (2007). Differential impact of Lhx2 deficiency on expression of class I and class II odorant receptor genes in mouse. Mol. Cell. Neurosci. 34, 679-688. DOI: https://doi.org/10.1016/j.cub.2005.09.010
Li, J., Ishii, T., Wen, D., and Mombaerts, P. (2005). Non-equivalence of cloned and clonal mice. Curr. Biol. 15, R756-757. DOI: https://doi.org/10.1016/j.cub.2005.09.010
Rothman, A., Feinstein, P., Hirota, J., and Mombaerts, P. (2005). The promoter of the mouse odorant receptor gene M71. Mol. Cell. Neurosci. 28, 535-546. DOI: https://doi.org/10.1016/j.mcn.2004.11.006
Feinstein, P., Bozza, T., Rodriguez, I., Vassalli, A., and Mombaerts, P. (2004). Axon guidance of mouse olfactory sensory neurons by odorant receptors and the β2 adrenergic receptor. Cell 117, 833-846. DOI: https://doi.org/10.1016/j.cell.2004.05.013
Feinstein, P., and Mombaerts, P. (2004). A contextual model for axonal sorting into glomeruli in the mouse olfactory system. Cell 117, 817-831. DOI: https://doi.org/10.1016/j.cell.2004.05.011
Li, J., Ishii, T., Feinstein, P., and Mombaerts, P. (2004). Odorant receptor gene choice is reset by nuclear transfer from mouse olfactory sensory neurons. Nature 428, 393-399. DOI: https://doi.org/10.1038/nature02433
Del Punta, K., Leinders-Zufall, T., Rodriguez, I., Jukam, D., Wysocki, C.J., Ogawa, S., Zufall, F., and Mombaerts, P. (2002). Deficient pheromone responses in mice lacking a cluster of vomeronasal receptor genes. Nature 419, 70-74. DOI: https://doi.org/10.1038/nature00955
Del Punta, K., Puche, A., Adams, N.C., Rodriguez, I., and Mombaerts, P. (2002). A divergent pattern of sensory axonal projections is rendered convergent by second-order neurons in the accessory olfactory bulb. Neuron 35, 1057-1066. DOI: https://doi.org/10.1016/s0896-6273(02)00904-2
Vassalli, A., Rothman, A., Feinstein, P., Zapotocky, M., and Mombaerts, P. (2002). Minigenes impart odorant receptor-specific axon guidance in the olfactory bulb. Neuron 35, 681-696. DOI: https://doi.org/10.1016/S0896-6273(02)00793-6
Bozza, T., Feinstein, P., Zheng, C., and Mombaerts, P. (2002). Odorant receptor expression defines functional units in the mouse olfactory system. J. Neurosci. 22, 3033-3043. DOI: https://doi.org/10.1523/JNEUROSCI.22-08-03033.2002
Rodriguez, I., Del Punta, K., Rothman, A., Ishii, T., and Mombaerts, P. (2002). Multiple new and isolated families within the mouse superfamily of V1r vomeronasal receptors. Nature Neurosci. 5, 134-139. DOI: https://doi.org/10.1038/nn795
Wakayama, T., Tabar, V., Rodriguez, I., Perry, A.C.F., Studer, L., and Mombaerts, P. (2001). Differentiation of embryonic stem cell lines generated from adult somatic cells by nuclear transfer. Science 292, 740-743. DOI: https://doi.org/10.1126/science.1059399
Wakayama, T., Rodriguez, I., Perry, A.C.F., Yanagimachi, R., and Mombaerts, P. (1999). Mice cloned from embryonic stem cells. Proc. Natl. Acad. Sci. USA 96, 14984-14989. DOI: https://doi.org/10.1073/pnas.96.26.14984
Rodriguez, I., Feinstein, P., and Mombaerts, P. (1999), Variable patterns of axonal projections of sensory neurons in the mouse vomeronasal system. Cell 97, 199-208. DOI: https://doi.org/10.1016/s0092-8674(00)80730-8